Pathology #7


Pathology #7







  1. What is the most common primary tumor arising within bone in adults?


    2. osteochondroma

    multiple myeloma

    acute lymphocytic leukemia

    neuroblastoma



  2. Hypercalcemia, renal insufficiency, and anemia is seen in which of the following?


    3. ALL

    CML

    multiple myeloma

    Renal osteodystrophy



  3. Failure of relaxation of the lower esophageal sphincter leads to what?


    4. achalasia

    GERD

    Barrett's esophagus

    Zenker's diverticulum



  4. All of the following are risk factors for esophageal cancer EXCEPT:


    5. smoking

    Zenker's diverticulum

    Plummer Vinson

    Whipple's disease



  5. Pernicious anemia is associated with what type of gastritis?


    6. Type A

    Type B

    All of the above

    none of the above



  6. Type B gastritis is caused by what?


    7. anti-parietal cell antibodies

    tropheryma whippeli

    helicobacter pylori

    anti-basement membrane antibody



  7. Which of the following is true of gastric ulcers


    8. pain decreases with meals

    almost 100% due to H. pylori

    Due to increase in gastric acid secretion

    Due to decrease in mucosal protection



  8. Which of the following is true of duodenal ulcers?


    9. NSAID use is indicated

    associated with weight loss

    clean, punched out margins

    H. pylori does not play a major role



  9. Erythema nodosum is an extraintestinal manifestation of what?


    10. Crohn's disease

    Ulcerative colitis

    all of the above

    none of the above



  10. Pain at McBurney's point can be all of the following EXCEPT?


    11. ectopic pregnancy

    ruptured spleen

    diverticulitis

    appendicitis






Pathology QQ #6






  1. Which type of lymphoma will most likely have the most Reed Sternberg cells?


    2. Nodular sclerosing

    Mixed cellularity Hodgkin's

    Non-Hodgkin's

    Lymphocyte depleted



  2. Which type of Hodgkin's lymphoma has the worst prognosis?


    3. Nodular sclerosing

    Mixed cellularity

    Lymphocyte predominant

    Lymphocyte depleted



  3. What Non-Hodgkin's lymphoma is associated with t(14:18) bcl-2 expression?


    4. Small lymphocytic

    follicular lymphoma

    Diffuse large cell

    Burkitt's lymphoma



  4. What Non-Hodgkin's lymphoma is associated with t(8:14)?


    5. Small lymphocytic

    Follicular lymphoma

    Diffuse large cell

    Burkitt's lymphoma



  5. Name the leukemia: affects children, most responsive to therapy?


    6. ALL

    AML

    CLL

    CML



  6. Name the leukemia: may accelerate to AML?


    7. ALL

    CLL

    CML

    None of the above



  7. Name the leukemia: Philadelphia chromosome?


    8. ALL

    AML

    CLL

    CML



  8. Name the leukemia: Auer rods in myeloblasts?


    9. ALL

    AML

    CLL

    CML



  9. Name the lymphoma: t(11:14)?


    10. Small lymphocytic

    Follicular

    Mantle cell lymphoma

    Burkitt's lymphoma



  10. Name the leukemia: t(15:17)?


    11. ALL

    AML

    CLL

    CML



You need a 10 out of 10 on this one!



Pathology QQ #5






  1. Presentation of this primary brain tumor includes papilledema, endocrine abnormalities, and bitemporal hemianopsia?


    2. pituitary adenoma

    medulloblastoma

    craniopharyngioma

    hemangioblastoma



  2. What supratentorial tumor is derived from remnants of Rathke's pouch?


    3. craniopharyngioma

    hemangioblastoma

    medulloblastoma

    ependymoma



  3. What tumor has perivascular rosettes with rod shaped blepharoplasts found near nucleus?


    4. pilocytic astrocytoma

    medulloblastoma

    ependymoma

    hemangioblastoma



  4. Which of the following primary tumors metastasize to the brain?


    5. kidney, pancreas, lung

    Breast, GI, Lung

    Thyroid, kidney, lung

    kidney, skin, prostate



  5. Which of the following primary tumors does NOT metastasize to the liver?


    6. Colon

    Prostate

    Pancreas

    Lung



  6. Renal cell carcinoma has what paraneoplastic effect?


    7. Cushing's syndrome

    hypocalcemia

    polycythemia

    Lambert-Eaton Syndrome



  7. Which of the following correlates to Iron deficient anemia?


    8. dec serum iron, dec TIBC, dec ferritin

    dec serum iron, inc TIBC, inc ferritin

    MCV > 100

    MCV < 80



  8. Increased risk of encapsulated organism infection, salmonella osteomyelitis, painful crisis?


    9. alpha-Thalassemia

    beta-Thalassemia

    aplastic anemia

    sickle cell anemia



  9. "Crew cut" on skull x-ray due to marrow expansion is seen in which of the following?


    10. sickle cell anemia

    alpha thalassemia

    beta thalassemia

    all of the above



  10. Small RBC's, inc MCHC, Coombs' negative, gallstones?


    11. Hereditary spherocytosis

    sickle cell anemia

    Bernard-Soulier disease

    alpha-thalassemia






Pathology QQ #4






  1. Which of the following chemical carcinogens does NOT affect the liver?


    2. Aflatoxins

    Vinyl Chloride

    Nitrosamines

    Carbon tetrachloride



  2. Which of the following chemical carcinogens affects the bladder?


    3. Arsenic

    Naphthalene dyes

    Carbon tetrachloride

    Nitrosamines



  3. Tumors that cause inflammation of the serosal surface can cause all of the following EXCEPT?


    4. pleural effusion

    ascites

    esophagitis

    pericardial effusion



  4. What type of skin cancer tumors have palisading nuclei?


    5. Squamous cell

    Basal Cell

    Melanoma

    all of the above



  5. What skin condition is a precursor to squamous cell carcinoma?


    6. Actinic keratosis

    Erythema multiforme

    Bullous pemphigoid

    Acanthosis nigricans



  6. What benign bone tumor commonly originates fron long metaphysis?


    7. Giant cell tumor

    Osteochondroma

    Enchondroma

    Ewing's sarcoma



  7. What bone tumor has a characteristic "double-bubble" appearance on x-ray?


    8. Osteosarcoma

    Giant Cell tumor

    Ewing's sarcoma

    Enchondroma



  8. What bone tumor is found in the pelvis, scapula, and is associated with a 11:22 translocation?


    9. Giant cell tumor

    Enchondroma

    Chondrosarcoma

    Ewing's Sarcoma



  9. What brain tumor can have both a compact and a loose palisading nuclei?


    10. Medulloblastoma

    Glioblastoma multiforme

    Schwannoma

    Oligodendroglioma



  10. What brain tumor has spindle cells concentrically arranged in a whorled pattern?


    11. Medulloblastoma

    Glioblastoma multiforme

    Meningioma

    Ependymoma






Pathology QQ #3






  1. Patient with pain, hematuria, hypertension, progressive renal failure, and autosomal dominant dz?


    2. Marfan's

    Adult polycystic kidney disease

    Tuberous sclerosis

    Hereditary spherocytosis



  2. A defect of fibroblast growth factor receptor 3 is found in this disease?


    3. Cretinism

    Hunter's disease

    Achondroplasia

    Fabry's disease



  3. All of the following are X-linked recessive EXCEPT?


    4. Hemophilia A

    Hemophilia B

    Lesch Nyhan syndrome

    Hereditary spherocytosis



  4. Abnormal growth with loss of cellular orientation, shape, and size is referred to as what?


    5. Hyperplasia

    Metaplasia

    Dysplasia

    Anaplasia



  5. Which of the following is incorrectly associated?


    6. Down syndrome- ALL

    Plummer Vinson Syndrome- Squamous cell of esophagus

    Acanthosis nigricans- malignant melanoma

    Actinic keratosis- squamous cell of the skin



  6. Which of the following genes are found on chromsome 17q?


    7. APC and WTI

    BRCA 1 and NF 1

    DPC and DCC

    BRCA 1 and BRCA 2



  7. Beta HCG is found elevated in all of the following EXCEPT?


    8. Ovarian tumors

    Hydatidiform moles

    Choriocarcinomas

    Gestational trophoblastic tumors



  8. What is Bombesin a known tumor marker for?


    9. Bone metastasis

    pancreatic cancer

    Neuroblastoma

    Medulloblastoma



  9. Which of the following oncogenes is paired incorrectly with its associated tumor?


    10. ret- MEN type II

    N-myc - Neuroblastoma

    erb-B2 - Uterine carcinoma

    bcl-2 - follicular lymphoma



  10. Nasopharyngeal carcinoma is associated with what virus?


    11. HBV

    EBV

    HPV

    HCV






Pathology QQ #2






  1. Characteristics of this disease include Gower's sign, pseudohypertrophy of the calves, and cardiac myopathy?


    2. Turner's syndrome

    Duchenne's muscular dystrophy

    Becker's dystrophy

    Double Y males



  2. All of the following are true about Turner's syndrome EXCEPT?


    3. ovarian dysgenesis

    Barr body

    webbing of neck

    coarctation of the aorta



  3. Congenital deletion of the short arm of what chromosome is involved in Cri-du-chat syndrome?


    4. 2

    4

    5

    15



  4. What is the second most common cause of genetic mental retardation?


    5. Down Syndrome

    Cri-du-chat

    Fragile X syndrome

    5-alpha reductase deficiency



  5. 22q11 Syndromes include all of the following EXCEPT?


    6. Abnormal facies

    DiGeorge syndrome

    Thymic aplasia

    Hypocalcemia



  6. What autosomal dominant disease has facial lesions, "ash leaf spots," and retinal hamartomas?


    7. Marfan's syndrome

    Neurofibromatosis type I

    Tuberous sclerosis

    von-Hippel Lindau



  7. Autosomal dominant, progressive dementia, caudate atrophy, gene on chromosome 4?


    8. Neurofibromatosis type II

    Phenylketonuria

    Friedreich's ataxia

    Huntington's disease



  8. Children with cystic fibrosis suffer from recurrent pulmonary infections from what bug?


    9. pseudomonas

    mycoplasma

    Haemophilus influenzae type B

    Legionella



  9. Failure of the bony spinal canal to close due to low folic acid intake occurs in what situation?


    10. Spina bifida occulta

    Meningocele

    Meningomyelocele

    all of the above



  10. At what time are newborns at highest risk of developing fetal alcohol syndrome?


    11. 3-8 weeks gestation

    12-16 weeks gestation

    20-24 weeks gestation

    30-36 weeks gestation






Pathology QQ #1


Pathology is without a doubt the most important subject to know for Step 1. Study and know it like the back of your hand!




  1. Which congenital malformation is associated with projectile vomiting?


    2. Hypospadias

    Cleft Lip

    Pyloric Stenosis

    Anencephaly



  2. All of the following are classified as a Right to Left shunt EXCEPT?


    3. Truncus arteriosus

    Patent ductus arteriosus

    Tetralogy of Fallot

    Tranposition of great vessels



  3. This congenital heart disease is heard as a continuous, machine-like murmur?


    4. VSD

    Truncus arteriosus

    ASD

    Patent ductus arteriosus



  4. Eisenmenger's syndrome can occur in all of the following situations EXCEPT?


    5. PDA

    VSD

    ASD

    Transposition of great vessels



  5. Which of the following about coarctation of the aorta is correctly paired?


    6. infantile type- preductal

    infantile type- postductal

    adult type- preductal

    infant and adult type- post ductal



  6. What congenital heart defect is seen in the offspring of diabetic mothers?


    7. Truncus arteriosus

    transposition of great vessels

    ASD

    Coarctation of the Aorta



  7. What syndrome occurs due to trisomy of chromosome 18?


    8. Down's

    Edwards

    Patau's

    Turner's



  8. What syndrome has a strong association with eventually developing alzheimer's disease?


    9. Down syndrome

    Edwards syndrome

    Patau's syndrome

    Turner's syndrome



  9. With what syndrome is there an increased risk of acute lymphocytic leukemia?


    10. Down syndrome

    Edwards syndrome

    Turner's syndrome

    Klinefelter's syndrome



  10. Duchenne's muscular dystrophy is due to what kind of mutation?


    11. Silent

    Missense

    Nonsense

    Frame shift